Publication Title

Alteration In Serum Levels Of Iron, Cobalt, Molybdenum, Chromium And Magnesium In Nephro-protected Rats Treated With Different Doses Of Methionine Containing Acetaminophen Formulation
Volume: 
6
Year of Publication: 
2011

Publication Abstract

Results of an earlier study that lasted twenty-four hours revealed alterations in the levels of some antioxidants and minerals, more importantly significant decreases were recorded for the indices of renal toxicity namely: urea and creatinine at different levels of exposure. This study was designed therefore to determine (lasting) effect of methionine\acetaminophen (paracetamol) formulation in the ratio of 1:9 on renal excretion of urea and creatinine at the end of 48th hour of exposure and to establish if this formulation causes interaction among essential trace elements. Eighteen male Wistar rats, weighing between 200-240g were dosed with different quantities of acetaminophen\methionine, six animals served as the control (received physiologic saline), three exposure groups consisting of six rats per group received the following dose regimen: 100 mg\kg BW (body weight); 350 mg\kg BW and 1000mg\kg BW. Results showed that urea, creatinine and uric acid were not significantly different in the exposed groups as compared to controls (p>0.05). On the other hand Fe, Mg, Cr, Mo and Co recorded significant alteration at one level of exposure or the other (p